Innovations in Managing Chronic Discomfort

This method involves using your body's own healing abilities to alleviate pain and facilitate recovery. PRF (platelet-rich fibrin) therapy harnesses platelets from your blood to create a concentrated fibrin matrix that can significantly accelerate the natural healing process and relieve orofacial pain when applied to the affected area.

Understanding that conditions like migraines and neck and shoulder discomfort often intersect with orofacial issues, our comprehensive approach at the Center aims to tackle the intricate web of pain. Our team is here to treat your symptoms and understand and address the root cause of your discomfort, providing you with a personalized and compassionate care plan. With a focus on minimally invasive and effective treatments, we are dedicated to improving your well-being and helping you reclaim the comfort and functionality you deserve.

What is Orofacial Pain?

Orofacial pain is a term used to describe any discomfort in the face or mouth, which can significantly affect your daily activities, such as eating, speaking, and sleeping. This pain can be sharp, throbbing, or a dull ache and can manifest in various parts of your orofacial region, including the jaws, cheeks, and around the eyes.

Types of Orofacial Pain

  • Muscle-related Pain: This includes discomfort stemming from overuse or tension in the facial and jaw muscles, often exacerbated by stress.
  • Joint-related Pain: Linked closely with the temporomandibular joint (TMJ), this pain can arise from dysfunction or inflammation.
  • Neuropathic Pain: Typically, a chronic pain that occurs due to nerve damage or malfunction within the orofacial region.

Causes and Symptoms

  • Bruxism: These are habits like teeth grinding or clenching that can significantly exert pressure on your teeth and jaw, leading to discomfort.
  • Myofascial Pain: It involves pain emanating from muscle knots or trigger points, which can radiate throughout your face and jaw.
  • Chronic Conditions: Conditions like migraines, headaches, and chronic pain in other body parts like the neck and shoulders can intertwine with orofacial discomfort.
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PRF Therapy in Orofacial Pain Management

PRF therapy offers an innovative approach to managing orofacial pain, harnessing the body's intrinsic healing mechanisms while maintaining a favorable safety profile. When you undergo PRF therapy, your blood creates a fibrin matrix rich in platelets and growth factors, which is then applied to the affected area to promote healing and alleviate pain.

The process involves a simple blood draw and centrifugation to isolate the PRF. When injected into the pain or injury site, the PRF growth factors stimulate tissue regeneration and reduce inflammation. You may experience relief from conditions such as temporomandibular joint disorders, neuralgia, and musculoskeletal pain post-treatment.

Indications for PRF Therapy

Expected Benefits

TMJ Disorders

Reduced inflammation


Accelerated nerve recovery

Post-surgical pain

Enhanced healing

What Are the Benefits of PRF Regenerative Therapy for Orofacial Pain?

  • Natural Healing Process: PRF therapy utilizes concentrations of your blood platelets, supporting and expediting the natural healing process.
  • Reduced Inflammation: The high concentration of growth factors in PRF can reduce inflammation, leading to less pain in the orofacial region.
  • Minimally Invasive: This therapy is less invasive than surgical alternatives, potentially resulting in shorter recovery times.
  • Low Risk of Allergic Reactions: Because PRF is derived from your blood, the risk of an allergic reaction is significantly decreased.
  • Minimal Side Effects: PRF therapy is associated with minimal side effects, a critical consideration for any treatment option.
  • Enhanced Tissue Regeneration: PRF promotes the regeneration of bone and soft tissue, which can be beneficial in various dental procedures and in the healing of orofacial tissues.
  • Pain Management: Patients have reported effective pain relief following PRF therapy, which is a primary concern when dealing with orofacial pain.
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Am I a Good Candidate for PRF Regenerative Therapy for Orofacial Pain?

When considering platelet-rich fibrin (PRF) regenerative therapy for orofacial pain, your health status and the nature of your condition are vital factors:

  • You experience chronic orofacial pain that hasn't responded well to conventional treatments
  • Your pain stems from conditions such as temporomandibular joint disorders, neuropathic pain, or after dental surgeries
  • You do not have blood disorders that affect clotting, as PRF relies on your body's ability to form clots for effectiveness
  • You have realistic expectations about the outcomes of PRF therapy and understand that multiple sessions might be needed

Exclusion criteria include the following:

  • You have an active infection in the area of the proposed treatment
  • You are taking medications that interfere with platelet function or blood clotting
  • Your medical history includes hematologic diseases (like hemophilia or chronic liver disease) that might affect platelet function and healing
  • You’re a smoker or have high alcohol consumption, which can negatively impact outcomes

There is never a condition “too complex”

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PRF Regenerative Therapy for Orofacial Pain: Procedure, Recovery, and Results


Similar to routine blood testing, a small amount of your blood is drawn. The collected blood is then spun in a centrifuge to separate the platelet-rich fibrin from other blood components.

Next, the isolated PRF is converted into a membrane or gel form, ready for application. Your specialist will apply the PRF to the affected areas in your mouth, utilizing its growth factors to promote healing and reduce pain.


One of the most significant benefits of PRF regenerative therapy is that it offers minimal downtime, which allows you to resume most daily activities immediately. You may experience some mild discomfort or swelling, which generally subsides within a few days. Additionally, you can use over-the-counter pain relievers or cold compresses for pain relief.


Many patients report a significant, long-term decrease in pain levels following the treatment. As a healing enhancement, PRF therapy can accelerate the healing of oral tissues.

Why Choose Us for PRF Regenerative Therapy for Orofacial Pain?

The San Francisco Center for TMJ & Sleep Apnea stands at the forefront of treating orofacial conditions, including TMJ and sleep apnea, with PRF Regenerative Therapy. This innovative treatment has the potential to significantly alleviate orofacial pain, a common symptom associated with TMJ and various other oral conditions.

Dr. Amin Samadian leads the charge at our center as a world-renowned expert in TMJ and orofacial therapies. Under his guidance, we champion evidence-based solutions to improve life quality. We offer a holistic approach to orofacial pain, addressing the underlying issues rather than just treating the symptoms. Additionally, our team collaborates across specialties to tailor treatments unique to your needs for optimal care.

You deserve a life free from orofacial pain. We invite you to book a consultation with us to embark on a path toward comfort and relief. Let us help you resolve your pain and improve your oral health through our specialized PRF Regenerative Therapy. Contact the San Francisco Center for TMJ & Sleep Apnea today and take the first step towards reclaiming your comfort and well-being.

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